
It's much more likely that Necromorph-Nicole is just another hallucination caused by the Marker.

The Necromorph would have had to travel all the way from the Ishimura, and there's really no way the Hive Mind controlling it could have known Isaac would eventually make it to the escape ship. It's not impossible that a Necromorph using Nicole's body managed to board the ship, but it is pretty unlikely. Just then the camera pans, and a Necromorph Nicole leaps out at Isaac before the screen cuts to black. Before getting too far into the message, Isaac turns it off and sits back in his chair. As he scans through the ship's computer, Nicole's final video message begins playing one last time on the holo screen. Isaac clearly appears to be alone in his space shuttle as he pulls away from the planet. The reasons behind the hallucination are mostly a mystery, but the implications are terrifying - another reminder of how the Marker can truly corrupt everything. At the same time, the Marker made Elizabeth see Isaac as her boyfriend Jacob Temple, who Dr. The entire time that Isaac has been on the Ishimura, the Marker has been infecting his mind, making him believe a woman named Elizabeth Cross is actually his doomed Nicole. This time, though, Isaac makes it all the way to the end of the video and sees Nicole die. Kendra forces Isaac to rewatch the video message from Nicole that he'd been viewing at the very start of the game.


Once Isaac returns the Marker to the planet's surface, the whole world seems poised to collapse, and Kendra confronts him with Nicole held at gunpoint. Throughout the entire game, Isaac has been hoping to reunite with his girlfriend Nicole Brennan, who'd been assigned to work on the Ishimura before it set sail for Aegis VII. That all changes near the end of the game when Kendra Daniels forces Isaac to have a shocking realization.
